Sirtris drug may fight diseases of age
[mrc] This article will be talking about the amazing benefits of resveratrol. However, as some of you may know; a new drug company is trying to turn the natural substance, resveratrol, into a drug.
Champion cyclist Lance Armstrong (center) has more powerful mitochondria, the "power packs of the cell," a Harvard professor says.
Sirtris Pharmaceuticals drug molecules could help boost patients'
mitochondria. Human testing begins next year.
NEW YORK - Scientists at Sirtris Pharmaceuticals Inc. say they have created a drug that mimics the ingredient in red wine linked to longevity and the cell structures that power endurance athletes like cycling champion Lance Armstrong.
[mrc] It is not yet an approved drug and so it is not yet available to anyone... at least not as a drug. Anyone can benefit from the Miracle
Molecule: resveratrol - one of the main ingredients in Symmetry's Genesis.
Click Here for Symmetry Direct Genesis Resveratrol!
The new molecule is 1,000 times more potent than the wine derivative, resveratrol, and could lead to solutions for diseases of aging, including cancer and diabetes, according to authors of a study in today's issue of the journal Nature.
[mrc] They are making the drug 1,000 times more concentrated to try and distinguish it from the natural substance. It is important to remember that all the original research that was done, was done with the amount of resveratrol found in one or two glasses of red wine, not a tremendously concentrated drug. Genesis provides you many times over the concentration of resveratrol used thousands and thousands of studies done around the world.
Researchers tested about 500,000 molecules for abilities to activate the immune-system booster SIRT1, the enzyme credited with resveratrol's ability to extend lifespans 30 to 70 percent in organisms from yeast and worms to flies and mice.
Human testing on the most promising ones will begin next year, said David Sinclair, an author of the study.
[mrc] Of course there is no reason to wait... we have the real molecule, the whole natural molecule right now!
"These are real drugs. This is not something out of red wine anymore,"
said Sinclair, a professor of pathology at Harvard Medical School and cofounder of Cambridge-based Sirtris. The study is "proof of a principle that you can put something into the food supply that will ward off and treat the diseases of aging in a single pill."
Sirtris's stock rose 7.8 percent to $18.38 yesterday. The company, which went public in May, had seen its share price climb 71 percent through Tuesday.
Mice and rats given three of the molecules responded like those in other experiments testing extreme calorie-restricting diets, even though the rodents continued to eat and weigh the same. They showed increased insulin sensitivity, lower blood-sugar levels, and more powerful mitochondria, the "power packs of the cell" that diminish with age.
"That's where it gets interesting," Sinclair said.
If you give resveratrol to a normal mouse, it can run twice as far because it has many more mitochondria, he said. Seven-time Tour de France winner Lance Armstrong has extra mitochondria that power his endurance abilities, Sinclair said.
[mrc] This is great news for athletes, casual weekend warriors, high school Lettermen, college players or professionals and again, this research was done with the amount of resveratrol in a glass or two of red wine, not a drug.
"The goal is not to make Lance Armstrongs of everyone, but you can imagine that it would boost the energy of someone who is frail and weak," Sinclair said.
Sirtris has about 140 patents and patent applications related to the so-called aging gene, and some of the most effective treatments for boosting SIRT1 were discovered after the Nature study was submitted for publication a year ago, Sinclair said. Results from animal studies of those drugs will be released next year, he said.
Sirtris was founded by Sinclair, chairman of its scientific board, and Christoph Westphal, the chief executive, to study activators of SIRT1 and its related class of enzymes. Other treatments for diseases of aging rely on complicated technology that may take years to develop, Westphal said.
The sirtuin gene was first reported by Leonard Guarente, a biology professor at Massachusetts Institute of Technology whose lab also discovered the aging benefits of restricted diets in mice. Sinclair, his post-doctoral student at the time, moved to Harvard in 1999 to develop drugs that could act in the same way. He discovered resveratrol in 2003.
[mrc] Actually he didn't "discover" resveratrol, research had been on- going since the 90's, it was 2003 when "he" discovered the molecule - Symmetry had already been working on Genesis for over 2 years by then. Click Here for Symmetry Direct Genesis Resveratrol!
If you have any questions about our products, simply call 646-335-7327. We're available to assist you as you start on the road to better health! You may also reach us by email at info@trevorz.com. Call today and give Symmetry Genesis a try. If you're not totally satisfied after 90 days of use, we'll refund your money. What do you have to lose?
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